While traditional hyaluronic acid dermal fillers remain excellent tools for providing immediate structural volume, the vanguard of aesthetic medicine is currently shifting toward true, biological tissue regeneration. Polynucleotides, which are derived from highly purified DNA fractions, represent a massive clinical advancement.

When introduced directly into the dermal layer, these powerful molecules do not merely occupy space; they actively stimulate fibroblasts to upregulate the endogenous production of fresh collagen, elastin, and hyaluronic acid. This specific modality is particularly efficacious for rejuvenating anatomically complex, delicate areas, such as the periocular region and the neck.